Московский семинар по биоинформатике - 21 марта 2013

Четверг, 21 марта 2013, 18.00
МГУ, Лаб. корпус Б (факультет биоинженерии и биоинформатики), к. 221.

Prof. Dr. Edgar Wingender
University Medical Center Goettingen and geneXplain GmbH, Germany

Constructions and analysis of gene regulatory networks

Gene regulatory networks comprising transcriptional and post-transcriptional events may provide a useful tool for characterizing regulatory processes of a cell with systems biological approaches. Using bioinformatic approaches for two independent criteria (predicted affinity and multi-genome conservativity), we have constructed the core of a transcriptional network for human cells. This network was expanded (a) by paralogous TF-target gene relations, based on a comprehensive transcription factor classification, and (b) by predicted and known microRNA-target gene relations. From the resulting gene regulatory reference network, a number of tissue-specific subnetworks could be extracted. They revealed structural particularities that seem to be characteristic for the different tissues.