Московский семинар по биоинформатике - 4 марта 2010

Артем Новожилов
Свойства и эволюция стандартного генетического кода.

Четверг, 4 марта 2010, 18.00
Институт молекулярной биологии (Вавилова, 32), к. 309.
Artem Novozhilov

On the origin and evolution of the standard genetic code

The genetic code is nearly universal, and the arrangement of the codons in the standard codon table is highly non-random. The fundamental question is how these regularities of the standard code came into being. In this talk I review the three main concepts on the origin and evolution of the genetic code, which are the stereochemical theory, the coevolution theory, and the error minimization theory. I present some recent results concerning the level of adaptation of the genetic code. I also discuss putative primordial genetic codes, which are shown to possess an exceptional level of robustness to mistranslations, and describe possible pathways of the code evolutionary expansion.

1. Novozhilov, Wolf, Koonin: Evolution of the genetic code: partial optimization of a random code for robustness to translation error in a rugged fitness landscape. Biology Direct 2007, 2:24. doi:10.1186/1745-6150-2-24
2. Novozhilov, Koonin: Exceptional error minimization in putative primordial genetic codes. Biology Direct 2009, 4:44. doi:10.1186/1745-6150-4-44.
3. Koonin, Novozhilov: Origin and evolution of the genetic code: The universal enigma, IUBMB Life, 61(2), 99-111, 2009



Рабочий язык семинара – русский

Заседания семинара проходят в Институте молекулярной биологии им. Энгельгардта РАН, ул. Вавилова 32, комната 309.

Сайт семинара (проезд, архив и т.д.): http://www.rtcb.iitp.ru/msb/Index.htm

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